Research

Transcription Factors (TFs) are at the apex of gene regulation. The entire genome, in principle, serves as a substrate for these factors, resulting in a large repertoire of binding sites. But a TF binds to a tiny subset of those. How is it driven? What binding events are functional? How multiple factors bind and how specificity is achieved? We try to answer these questions.

We are at the intersection of Computational and Experimental Biology. We often derive hypotheses from existing in vitro, in vivo, and structural data to answer key questions in the field of regulatory genomics. 

We extensively use DNA methylation in all possible ways. For instance, we use DNA methylation as a probe to map chromatin dynamics at single-molecule resolution.